This is a common question that comes up in the neurologists’ office, regardless of age of the patient.  It arises not just from concern for family members, but also as a matter of curiosity, of explanation.

We used to believe that Parkinson Disease was almost entirely caused by environmental factors.  20 years ago, genetic involvement was deemed to be around 2% of cases or less.  Through the advent of advanced and increasingly affordable genetic testing, as well as improved collaboration across the globe, we now believe that genes account for at least 8% of PD, perhaps up to 15% based on more recent data.  People with Young Onset Parkinson Disease, those with dystonia early on, and those with symmetric (both sides) findings are probably more likely to have a genetic cause than the more typical patients.

Yes, some environmental factors have been linked to increased risk of PD, such as pesticides, herbicides, fungicides, some heavy metals, and, perhaps, living in North America, but the linkage or direct cause is not as obvious as one might hope.  To date, the use of surveys and questionnaires has produced few, if any, clues to the causes of PD.

The virtual revolution that has occurred in genetic testing in the past 20-odd years has allowed us to identify quite a few genes that seem to cause PD, perhaps 15 or 20 genes that are under study, with more being identified at an increasing rate.  In a recent interview with Medscape Medical News, Owen A. Ross, PhD, a neuroscientist at the Mayo Clinic said ”The idea that [PD] occurs mostly in a random sporadic fashion is changing.”   Dr. Ross was part of consortium of PD researchers who published an online report August 31 in Lancet Neurology. The Genetic Epidemiology of Parkinson’s Disease (GEO-PD) consortium reported the identification of both risk and protective variants in the LRRK2 gene, perhaps the most notorious PD gene both for its dominant inheritance (50% of offspring inherit the gene) and for its association with Sergay Brin, the co-founder of Google who inherited LRRK2 from his mother.  Dr. Ross and colleagues found that, while some forms seem to carry increased risk of PD, others may protect against PD to some extent.

Obviously, as in many things, our view of the cause of PD is vastly different than it was just 10 years ago.  Hopefully, we will be eventually be able to get a handle on prevention of PD as well as a more satisfying treatment or even a cure.



03/20/2014 8:18am

i am glad to be here i really enjoyed your post while reading it, it's an interesting one, i will look forward more posts of yours. thanks alot.

03/20/2014 8:19am

Such an amazing article! I really enjoy reading it, very good insights, the article is very ell-said. A thumbs up!

04/03/2014 3:07am

My spouse and i was furthermore looking for linked goods by while. you've got resolved my trouble. thank you with regard to supplying this kind of incredible goods in order to all of us.

09/16/2014 11:50pm

how do you get this information? allow me to use as a final exam ?? thank you very nice blog

I do not know whether you like it or not when I say the blog is very nice and cool. But certainly this blog is really cool and helpful. Thank you

05/21/2015 5:02am

I sometimes feel dissapointed about why failed to find this interesting weblog considering that the very first purchase akau science keeps growing because it is these days.

The life is composed if the different and various stages and steps. The stages of the life are divided in accordance to the convenience of the human beings and individuals. The studies are also provided keeping in view this comfort zone.

12/27/2015 8:33am

You could definitely see your expertise in the work you write. The sector hopes for even more passionate writers such as you who are not afraid to say how they believe. Always go after your heart

04/18/2016 4:28am

Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point. You obviously know what youre talking about, why waste your intelligence on just posting videos to your weblog when you could be giving us something informative to read?

This is telling abou parkinson disease genetic topics on the post. So every user should read the following articles and posts from this website. Then, you can understood every article from this clinical blog, and thank you.

Comments are closed.